Anti-Smac/DIABLO抗體,線粒體促凋亡蛋白抗體產品詳細資料

產品編號 BYK-1298R

英文名稱 Smac
中文名稱 線粒體促凋亡蛋白抗體
別    名 Smac / Diablo; 0610041G12Rik; DBLOH_HUMAN; DBOH; DBOH; diablo; Diablo homolog (Drosophila); Diablo homolog (Drosophila); Diablo homolog; Diablo homolog Drosophila; Diablo homolog mitochondrial; Diablo homolog mitochondrial precursor; DIABLO S; DIABLO S; DIABLOS; Direct IAP binding protein with low pI; Direct IAP-binding protein with low pI; FLJ10537; FLJ25049; mitochondrial; Mitochondrial Smac protein; Second Mitochondria Derived Activator of Caspase; Second mitochondria-derived activator of caspase; SMAC 3; smac; Smac protein; SMAC3.
研究領域 腫瘤  細胞生物  細胞凋亡  新陳代謝  線粒體  
分 子 量 21kDa
細胞定位 細胞漿 線粒體

抗體來源 Mouse or Rabbit
克隆類型 Monoclonal or Polyclonal
產品應用 WB、ELISA、IHC-P、IHC-F、Flow-Cyt、IF、IP、ICC 此產品應用不做依據，具體產品應用與實驗稀釋比請！

not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.


     Anti-Smac/DIABLO抗體,線粒體促凋亡蛋白抗體產品介紹 

      This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively. The inhibitor of apoptosis (IAP) proteins regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes their inhibitory effect on caspases has been designated Smac/DIABLO. This is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates the cytochrome c/Apaf-1/caspase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases. Smac/DIABLO is expressed in a variety of human and mouse tissues. 

 此相關標記有：Alexa Fluor 350 標記、Alexa Fluor 488 標記、Alexa Fluor 555 標記、Alexa Fluor 647 標記、AP標記、APC標記、Biotin標記、Cy3標記、Cy5標記、Cy5.5標記、Cy7標記、FITC標記、Gold標記、HRP標記、PE標記、PE-Cy3標記、PE-CY5標記、PE-CY5.5標記、PE-CY7標記、RBITC標記 

     相關產品：

     Anti-GRK3抗體,β腎上腺素能受體激酶2抗體

Anti-GPM6A抗體,神經細胞膜糖蛋白M6a抗體
Anti-GBA抗體,β-葡萄糖腦苷脂酶抗體
Anti-GHRHR抗體,生長激素釋放因子受體抗體
Anti-GPR10抗體,G蛋白偶聯受體10抗體
Anti-GDF6抗體,生長分化因子6抗體
Anti-GEFT抗體,*核苷酸交換因子GEFT抗體
Anti-GMF beta抗體,膠漿成熟因子β抗體
Anti-GPM6B抗體,神經細胞膜糖蛋白M6b
Anti-GPR56抗體,蛋白偶聯受體56抗體
Anti-Gbx2抗體,腸和大腦特定同源蛋白2抗體
Anti-Glutathione Synthetase抗體,*合成酶抗體
Anti-Glyt1抗體,*轉運蛋白1抗體
Anti-Gsh1抗體,生長激素釋放激素同源盒蛋白1抗體
Anti-GCDFP15抗體,特異性囊腫病液體蛋白15
Anti-GATAD1抗體,眼發育相關基因蛋白ODAG抗體
Anti-GNAL抗體,腺苷酸環化酶Gα蛋白抗體
Anti-GRIK2抗體,*受體紅藻氨酸離子2/*受體6抗體
Anti-GluA4抗體,離子型*受體4抗體
Anti-phospho-GluA4(Ser862),磷酸化離子型*受體4抗體