Anti-Aph-1b抗體,早老素穩定因子樣蛋白抗體說明書產品詳細資料

產品編號 BYK-11640R

英文名稱 Aph-1b
中文名稱 早老素穩定因子樣蛋白/γ分泌酶組件蛋白APH1抗體
別    名 Anterior pharynx defective 1; Anterior pharynx defective 1 homolog B (C. elegans); Anterior pharynx defective 1 homolog B; Anterior pharynx defective 1B like; Anterior pharynx defective 1b short splicing variant; APH 1B; Aph 1beta; APH-1b; Aph-1beta; Aph1 beta; aph1b; APH1B_HUMAN; Aph1beta; Gamma secretase subunit APH 1B; Gamma secretase subunit APH1B; Gamma secretase sununit; Gamma-secretase subunit Aph-1b; Presenilin stabilisation factor like; Presenilin-stabilization factor-like; PRO 1328; PRO1328; PSFL; TAAV 688; TAAV688.
研究領域 細胞生物  神經生物學  Alzheimer's  

抗體來源 Mouse or Rabbit

克隆類型 Monoclonal or Polyclonal
產品應用 WB、ELISA、IHC-P、IHC-F、Flow-Cyt、IF、IP、ICC 此產品應用不做依據，具體產品應用與實驗稀釋比請！

not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.


     Anti-Aph-1b抗體,早老素穩定因子樣蛋白抗體說明書產品介紹： 

      Anterior pharynx defective 1 (Aph-1) is a polytopic, seven-pass membrane protein that functions as one of the four essential components in the presenilin-Gamma-secretase enzyme complex. This enzyme complex is necessary for the intra-membrane proteolysis of several different membrane proteins, including the beta-Amyloid precursor protein, and is involved in multiple neurodevelopmental signaling pathways. Aph-1b and Aph-1a are splice variants of Aph-1. Aph-1b specifically lacks exon 4, which encodes for the entire fourth transmembrane domain, causing the protein to be destabilized. Deficiency of Aph-1a causes a reduction in Gamma-secretase activity, however deficiency of Aph-1b does not; thus, Aph-1b may execute redundant functions in the cell. Aph-1b expression and Gamma-secretase activity may be implicated in neurodevelopmental disorders, such as schizophrenia.

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